A new study shows evidence that extremely high doses of CBD can damage the liver. Although extremely high doses of CBD taken daily have been associated with liver toxicity, so have other supplements and medications. Therefore, it's best to keep your CBD consumption within reason. Doses as high as 20 mg of CBD per kg pose no threat to liver health, as proven in the clinical trial of Epidiolex, a CBD-based anticonvulsant medication.
Cannabidiol restores liver function, normalizes 5-HT levels, and improves brain pathology in accordance with the normalization of brain function. Therefore, the effects of cannabidiol may be the result of a combination of its actions on the liver and brain. Alcohol abuse and liver diseases induced by a high-fat diet have been the most prevalent chronic liver diseases and the main reasons for liver transplantation worldwide. Cannabidiol (CBD) is a botanical component extracted from marijuana plants without psychoactive impact.
In our previous reports, we found that CBD can prevent fatty liver induced by the Lieber-Decarli ethanol diet or non-alcoholic fatty liver disease (NAFLD) induced by a diet high in fat and cholesterol. The current work is an additional study on whether CBD can alleviate ethanol-induced liver damage plus the high-fat cholesterol diet (EHFD), which is a model that simulates excessive alcohol drinkers on a Western diet. An EHFD-induced mouse liver injury model was applied for 8 weeks to explore the protective properties of CBD and the underlying mechanisms. We found that CBD prevents hepatic steatosis and oxidative stress induced by EHFD.
CBD treatment inhibited macrophage recruitment and suppressed the activation of the NFκB-NLRP3-pyroptosis pathway in the liver of mice. The hepatoprotective property of CBD in the current model could be the result of inhibition of inflammation by alleviating the activation of the hepatic NFκB (NLRP3 inflammasome) pyroptosis pathway by CBD.
